I-Tranexamic Acid(1197-18-8)
Incazelo Yomkhiqizo
● I-Tranexamic Acid(1197-18-8)
● Inombolo ye-CAS: · 1197-18-8
● I-EINECS No.: 356.2222
● MF: C8H15NO2
● Iphakheji: 25Kg/Drum
● I-Tranexamic acid (TXA) iwumuthi osetshenziselwa ukwelapha noma ukuvimbela ukulahlekelwa igazi eliningi ngenxa yokuhlukumezeka okukhulu, ukopha kwangemva kokubeletha, ukuhlinzwa, ukukhishwa kwamazinyo, ukopha, nokuya esikhathini kakhulu.[2][3]Iphinde isetshenziselwe i-angioedema yofuzo.[2][4]Ithathwa ngomlomo noma ngomjovo emthanjeni.
Indlela yokwenza
I-Tranexamic acid iyi-analog yokwenziwa ye-amino acid lysine.Isebenza njenge-antifibrinolytic ngokubopha ngokuhlehla izizinda ezine kuya kwezinhlanu ze-lysine receptor ku-plasminogen.Lokhu kunciphisa ukuguqulwa kwe-plasminogen ku-plasmin, kuvimbele ukuwohloka kwe-fibrin futhi kulondoloze uhlaka lwesakhiwo se-matrix ye-fibrin. I-Tranexamic acid inomsebenzi cishe ophindwe kasishiyagalombili kunomsebenzi we-antifibrinolytic we-analogue endala, i-ε-aminocaproic acid. umsebenzi we-plasmin enamandla abuthakathaka (IC50 = 87 mM), futhi ingavimba indawo esebenzayo ye-urokinase plasminogen activator (i-uPA) ngokucaciswa okuphezulu (Ki = 2 mM), okungenye ephezulu kakhulu kuwo wonke ama-serine proteases.
Imisebenzi ye-Tranexamic acid
I-Tranexamic acid isetshenziswa kaningi kulandela ukuhlukumezeka okukhulu.[13]I-Tranexamic acid isetshenziselwa ukuvimbela nokwelapha ukulahleka kwegazi ezimeni ezihlukahlukene, njengezinqubo zamazinyo, ukopha okukhulu kokuya esikhathini, nokuhlinzwa okunengozi enkulu yokulahlekelwa igazi.
| Izinto Zokuhlola | I-Pharmacopeial Criteria | Umphumela Wokuhlola | |
| ABALINGISI | Ukubukeka: Impushana emhlophe noma ecishe ibe mhlophe, eyikristalu | I-crystalline powder emhlophe | |
| Ukunyibilika: Incibilika ngokukhululeka emanzini naku-glacial acetic acid, cishe ayincibiliki ku-acetone naku-ethanol (96%). | Dlula | ||
| UKUKHOMBA | I-Infrared Absorption Spectrophotometry: I-IR spectrum ihambisana ne-Tranexamic acid CRS | Dlula | |
| TEST | i-pH (2,2.3) | 7.0 〜8.0 | 7.4 |
| Izinto Ezihlobene (HPLC2.2.29) | Ukungcola A≤ 0.1 % | Akutholwanga | |
| Ukungcola B≤ 0.2% | 0.03% | ||
| UkungcolaC Ukungcola okungashiwongo≤ 0.10% Ukungcola D Okunye Ukungcola | 0.002% 0.001% Akutholwanga | ||
| Isamba sokungcola okungashiwongo≤ 0.2% | 0.003% | ||
| I-Halides Evezwe Njenge-Chlorides | ≤140ppm | <140ppm | |
| Ukulahlekelwa Ekumisweni | ≤0.5% | 0.026% | |
| Umlotha one-sulphate | ≤0.1% | 0.027% | |
| I-ASSAY | Kufanele kube ngaphakathi (Okomisiwe) 99.0% 〜101.0% | 100.1% | |
