I-Gliclazide(21187-98-4)
Uhlu Lomkhiqizo
I-Gliclazide iyisidakamizwa se-sulfonylurea somlomo se-antidiabetic.I-crystalline emhlophe noma i-crystalline powder, ayinaphunga futhi ayinambitheki.
I-Gliclazide iyi-ejenti ye-hypoglycemic yesizukulwane sesibili yomlomo ye-sulfonylurea enesenzo esiqinile.Indlela yayo iyafana neye-toluenosulfonylurea, okungukuthi, ngokukhetha isebenza kuma-pancreatic β-cell ukukhuthaza ukukhiqizwa kwe-insulin futhi ithuthukise ukukhululwa kwe-insulin ngemuva kokudla i-glucose, engakwazi nje ukuthuthukisa imetabolism yeziguli ezinesifo sikashukela, kodwa futhi ithuthukise noma ibambezele ukwenzeka kwesifo sikashukela. izinkinga ze-vascular diabetes.
I-Gliclazide isetshenziselwa ikakhulukazi uhlobo lwe-II yesifo sikashukela esithambile nesilinganiselayo esiqala kubantu abadala lapho ukulawulwa kokudla nokuzivocavoca kukodwa kungasebenzi futhi ngaphandle kokuthambekela kwe-ketosis, futhi ithuthukisa izilonda ze-fundus kanye nokungasebenzi kahle kwe-metabolic nemithambo ezigulini ezinesifo sikashukela.
Isicelo
I-Gliclazide isetshenziselwa ukulawula i-hyperglycemia ku-mellitus yesifo sikashukela esizinzile, esithambile, esingeyona i-ketosis, uhlobo 2 lwesifo sikashukela.Isetshenziswa lapho isifo sikashukela singakwazi ukulawulwa ngokudla ngendlela efanele kanye nokuvivinya umzimba noma lapho ukwelashwa nge-insulin kungafanele.[okushiwo] I-National Kidney Foundation ithi i-Gliclazide ayidingi ukunyuswa kwemithamo ngisho nalapho isifo sezinso sesiphelile.
| Hlola | Imininingwane | Imiphumela yokuhlaziya |
| Ukubukeka | Impushana emhlophe noma ecishe ibe mhlophe. | Impushana emhlophe |
| Ukuncibilika | Ayincibiliki emanzini;i-soluble ngokukhululekile ku-methylene chloride;i-soluble kancane ku-acetone;incibilika kancane ku-ethanol (amaphesenti angama-96). | Ihlangabezana nezidingo |
| Izimpawu | I-spectrum yokumuncwa kwe-infrared ihambisana naleyo etholwe nge-gliclazide CRS. | Ihlangabezana nezidingo |
| Ukungcola B (Nge-HPLC) | ≤2ppm | 0.5ppm |
| Izinsimbi ezinzima | ≤10ppm | <10ppm |
| Izinto ezihlobene (Nge-HPLC) | Ukungcola F ≤0.1% | Ayitholakali |
| Ukungcola ngakunye okungashiwongo ≤0.10% | 0.04% | |
| Isamba sokungcola ngaphandle kuka-F ≤0.2% | 0.11% | |
| Ukulahlekelwa ekomisweni | ≤0.25% | 0.11% |
| Umlotha one-sulfate | ≤0.1% | 0.03% |
| Izinyibilikisi ezisele (Nge-GC) | I-Ethyl acetate NMT 2500 ppm | 265ppm |
| N,N-Dimethylformamide NMT 880 ppm | Ayitholakali | |
| Isivivinyo | 99.0-101.0%, ngesisekelo esomisiwe. | 100.0% |
| Isiphetho | Imiphumela yokuhlolwa ihambisana ne-EP8. | |
