I-Ceftiofur Hydrochloride(103980-44-5)
Incazelo Yomkhiqizo
I-Ceftiofur iyimithi elwa namagciwane yohlobo lwe-cephalosporin (isizukulwane sesithathu), enelayisensi yokusetshenziswa ekwelashweni kwezilwane.Yaqala ukuchazwa ngo-1987.
Iyakwazi ukumelana ne-enzayimu yokumelana nama-antibiotic i-beta-lactamase, futhi inomsebenzi ngokumelene namabhaktheriya e-Gram-positive kanye ne-Gram-negative.Izinhlobo ze-E. coli ezimelana ne-ceftiofur ziye zabikwa.
I-Ceftiofur Hydrochloride iwuhlobo lukasawoti lwe-hydrochloride lwe-ceftiofur, i-semisynthetic, i-beta-lactamase-stable, i-broad-spectrum, i-cephalosporin yesizukulwane sesithathu enomsebenzi wokulwa namagciwane.I-Ceftiofur ibophezela futhi ivimbe amaprotheni abopha i-penicillin (PBPs) atholakala kulwelwesi lwangaphakathi lodonga lweseli yebhaktheriya.Ama-PBP ama-enzyme abandakanyeka ezigabeni zokugcina zokuhlanganisa udonga lweseli yebhaktheriya kanye nasekubumbeni kabusha udonga lweseli ngesikhathi sokukhula nokuhlukana.Ukungasebenzi kwama-PBP kuphazamisa ukuxhumana okuphambanayo kwamaketango e-peptidoglycan adingekayo ukuze kuqine udonga lwamaseli ebhaktheriya kanye nokuqina.Lokhu kubangela ukuthi udonga lwamangqamuzana amagciwane lube buthaka futhi lubangele i-cell lysis.
| IZINTO | IMICIMBI | IMIPHUMELA | |
| Ukubukeka | Impushana ye-Crystalline emhlophe ukuya kokumhlophe | Vumelanisa | |
| Ukuhlonza | Isikhathi sokugcina sesiqongo esiyinhloko ku- ichromatogram etholwe ngesixazululo sokuhlola ama-correspoons kulelo lokuphakama okuyinhloko ku ichromatogram etholwe ngesixazululo sereferensi. | Vumelanisa | |
| Ukusabela kweChloride | Vumelanisa | ||
| Ukubukeka kwesixazululo | Ukucaca | Ayinamandla kune-No.1 Turbidity Standard | <1 |
| Umbala | Ayimnyama kunesixazululo esijwayelekile esingu-Y9 | <8 | |
| Ukuncibilika | Incibilika ku-N, N- Dimethylacetamide, kancane Incibilika ku-5% we-sodium bicarbonate ne-methanol. | Vumelanisa | |
| PH | 2.0~3.0 | 2.2 | |
| Okuqukethwe Amanzi | 1.5%~4.0% | 1.6% | |
| Ukujikeleza kokubona okuqondile | -115°~-127° | -117° | |
| Insimbi enzima | I-NMT 0.0020% | Vumelanisa | |
| Insalela yokushisa | I-NMT 0.20% | 0.15% | |
| Izinto ezihlobene | Ukungcola okukhulu kakhulu | I-NMT 0.20% | 0.09 |
| Ukungcola okuphelele | I-NMT 1.50% | 0.38 | |
| Izincibilikisi ezisele | I-Ethyl Acetate | I-NMT 0.5000% | 0 |
| I-THF | I-NMT 0.0720% | 0.006 | |
| I-acetone | I-NMT 0.5000% | 0.2739% | |
| Benzeni | I-NMT 0.0002% | 0.0001 | |
| Isivivinyo | I-Ceftiofur Hydrochloride | I-NLT 98.0% | 100.4% |
| I-Chloride | 6.0%~6.5% | 6.2% | |
| I-Endotoxin yebhaktheriya | Ngaphansi kuka-0.20EU/mg | Vumelanisa | |
| Ubunyumba | Ivumelana nokuhlola | Vumelanisa | |
| Usayizi wezinhlayiya | D (0,1) | <1 | 1.8 |
| D (0,5) | <4 | 1.4 | |
| D (0,9) | <7 | 3.7 | |
| D (1,0) | <10 | 4.2 | |
| ISIPHETHO | IMIPHUMELA YESIVIVINYO IHAMBISANA NEMICACISO | ||
