I-Ceftiofur Hydrochloride(103980-44-5)
Incazelo Yomkhiqizo
I-Ceftiofur iyimithi elwa namagciwane yohlobo lwe-cephalosporin (isizukulwane sesithathu), enelayisensi yokusetshenziswa ekwelashweni kwezilwane.Yaqala ukuchazwa ngo-1987.
Iyakwazi ukumelana ne-enzayimu yokumelana nama-antibiotic i-beta-lactamase, futhi inomsebenzi ngokumelene namabhaktheriya e-Gram-positive kanye ne-Gram-negative.Izinhlobo ze-E. coli ezimelana ne-ceftiofur ziye zabikwa.
I-Ceftiofur Hydrochloride iwuhlobo lukasawoti lwe-hydrochloride lwe-ceftiofur, i-semisynthetic, i-beta-lactamase-stable, i-spectrum ebanzi, i-cephalosporin yesizukulwane sesithathu enomsebenzi wokulwa namagciwane.I-Ceftiofur ibopha futhi ivimbe amaprotheni abopha i-penicillin (PBPs) atholakala kulwelwesi lwangaphakathi lodonga lweseli yebhaktheriya.Ama-PBP ama-enzyme abandakanyeka ezigabeni zokugcina zokuhlanganisa udonga lweseli yebhaktheriya kanye nasekubumbeni kabusha udonga lweseli ngesikhathi sokukhula nokuhlukana.Ukungasebenzi kwama-PBP kuphazamisa ukuxhumana okuphambanayo kwamaketango e-peptidoglycan adingekayo ukuze kuqine udonga lwamaseli ebhaktheriya kanye nokuqina.Lokhu kubangela ukuthi udonga lwamangqamuzana amagciwane lube buthaka futhi lubangele i-cell lysis.
IZINTO | IMICIMBI | IMIPHUMELA | |
Ukubukeka | Impushana ye-Crystalline emhlophe ukuya kokumhlophe | Vumelanisa | |
Ukuhlonza | Isikhathi sokugcina sesiqongo esiyinhloko ku- ichromatogram etholwe ngesixazululo sokuhlola ama-correspoons kulelo lokuphakama okuyinhloko ku ichromatogram etholwe ngesixazululo sereferensi. | Vumelanisa | |
Ukusabela kweChloride | Vumelanisa | ||
Ukubukeka kwesixazululo | Ukucaca | Ayinamandla kune-No.1 Turbidity Standard | <1 |
Umbala | Ayimnyama kunesixazululo esijwayelekile esingu-Y9 | <8 | |
Ukuncibilika | Incibilika ku-N, N- Dimethylacetamide, kancane Incibilika ku-5% we-sodium bicarbonate ne-methanol. | Vumelanisa | |
PH | 2.0~3.0 | 2.2 | |
Okuqukethwe Amanzi | 1.5%~4.0% | 1.6% | |
Ukujikeleza kokubona okuqondile | -115°~-127° | -117° | |
Insimbi enzima | I-NMT 0.0020% | Vumelanisa | |
Insalela yokushisa | I-NMT 0.20% | 0.15% | |
Izinto ezihlobene | Ukungcola okukhulu kakhulu | I-NMT 0.20% | 0.09 |
Ukungcola okuphelele | I-NMT 1.50% | 0.38 | |
Izincibilikisi ezisele | I-Ethyl Acetate | I-NMT 0.5000% | 0 |
I-THF | I-NMT 0.0720% | 0.006 | |
I-acetone | I-NMT 0.5000% | 0.2739% | |
Benzeni | I-NMT 0.0002% | 0.0001 | |
Isivivinyo | I-Ceftiofur Hydrochloride | I-NLT 98.0% | 100.4% |
I-Chloride | 6.0%~6.5% | 6.2% | |
I-Endotoxin yebhaktheriya | Ngaphansi kuka-0.20EU/mg | Vumelanisa | |
Ubunyumba | Ivumelana nokuhlola | Vumelanisa | |
Usayizi wezinhlayiya | D (0,1) | <1 | 1.8 |
D (0,5) | <4 | 1.4 | |
D (0,9) | <7 | 3.7 | |
D (1,0) | <10 | 4.2 | |
ISIPHETHO | IMIPHUMELA YESIVIVINYO IHAMBISANA NEMICACISO |