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I-Ceftiofur Hydrochloride(103980-44-5) Isithombe Esifakiwe
  • I-Ceftiofur Hydrochloride(103980-44-5)

I-Ceftiofur Hydrochloride(103980-44-5)


Inombolo ye-CAS: 103980-44-5

Inombolo ye-EINECS: 560.0235

MF: C19H18ClN5O7S3

Incazelo Yomkhiqizo

Incazelo Entsha

Incazelo Yomkhiqizo

I-Ceftiofur iyimithi elwa namagciwane yohlobo lwe-cephalosporin (isizukulwane sesithathu), enelayisensi yokusetshenziswa ekwelashweni kwezilwane.Yaqala ukuchazwa ngo-1987.

Iyakwazi ukumelana ne-enzayimu yokumelana nama-antibiotic i-beta-lactamase, futhi inomsebenzi ngokumelene namabhaktheriya e-Gram-positive kanye ne-Gram-negative.Izinhlobo ze-E. coli ezimelana ne-ceftiofur ziye zabikwa.

I-Ceftiofur Hydrochloride iwuhlobo lukasawoti lwe-hydrochloride lwe-ceftiofur, i-semisynthetic, i-beta-lactamase-stable, i-spectrum ebanzi, i-cephalosporin yesizukulwane sesithathu enomsebenzi wokulwa namagciwane.I-Ceftiofur ibopha futhi ivimbe amaprotheni abopha i-penicillin (PBPs) atholakala kulwelwesi lwangaphakathi lodonga lweseli yebhaktheriya.Ama-PBP ama-enzyme abandakanyeka ezigabeni zokugcina zokuhlanganisa udonga lweseli yebhaktheriya kanye nasekubumbeni kabusha udonga lweseli ngesikhathi sokukhula nokuhlukana.Ukungasebenzi kwama-PBP kuphazamisa ukuxhumana okuphambanayo kwamaketango e-peptidoglycan adingekayo ukuze kuqine udonga lwamaseli ebhaktheriya kanye nokuqina.Lokhu kubangela ukuthi udonga lwamangqamuzana amagciwane lube buthaka futhi lubangele i-cell lysis.

IZINTO

IMICIMBI

IMIPHUMELA

Ukubukeka

Impushana ye-Crystalline emhlophe ukuya kokumhlophe

Vumelanisa

Ukuhlonza

Isikhathi sokugcina sesiqongo esiyinhloko ku-

ichromatogram etholwe ngesixazululo sokuhlola

ama-correspoons kulelo lokuphakama okuyinhloko ku

ichromatogram etholwe ngesixazululo sereferensi.

Vumelanisa

Ukusabela kweChloride

Vumelanisa

Ukubukeka kwesixazululo

Ukucaca

Ayinamandla kune-No.1 Turbidity Standard

<1

Umbala

Ayimnyama kunesixazululo esijwayelekile esingu-Y9

<8

Ukuncibilika

Incibilika ku-N, N- Dimethylacetamide, kancane

Incibilika ku-5% we-sodium bicarbonate ne-methanol.

Vumelanisa

PH

2.0~3.0

2.2

Okuqukethwe Amanzi

1.5%~4.0%

1.6%

Ukujikeleza kokubona okuqondile

-115°~-127°

-117°

Insimbi enzima

I-NMT 0.0020%

Vumelanisa

Insalela yokushisa

I-NMT 0.20%

0.15%

Izinto ezihlobene

Ukungcola okukhulu kakhulu

I-NMT 0.20%

0.09

Ukungcola okuphelele

I-NMT 1.50%

0.38

Izincibilikisi ezisele

I-Ethyl Acetate

I-NMT 0.5000%

0

I-THF

I-NMT 0.0720%

0.006

I-acetone

I-NMT 0.5000%

0.2739%

Benzeni

I-NMT 0.0002%

0.0001

Isivivinyo

I-Ceftiofur Hydrochloride

I-NLT 98.0%

100.4%

I-Chloride

6.0%~6.5%

6.2%

I-Endotoxin yebhaktheriya

Ngaphansi kuka-0.20EU/mg

Vumelanisa

Ubunyumba

Ivumelana nokuhlola

Vumelanisa

Usayizi wezinhlayiya

D (0,1)

<1

1.8

D (0,5)

<4

1.4

D (0,9)

<7

3.7

D (1,0)

<10

4.2

ISIPHETHO

IMIPHUMELA YESIVIVINYO IHAMBISANA NEMICACISO


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