I-Uricase(UA-R) evela ku-Microorganism
Incazelo
Le enzyme ilusizo ku-enzymatic determi nation ye-uric acid ekuhlaziyweni komtholampilo.I-Uricase ibamba iqhaza ku-purine catabolism.Igqugquzela ukuguqulwa kwe-uric acid engancibiliki kakhulu ibe yi-5-hydroxyisourate.Ukunqwabelana kwe-uric acid kubangela ukulimala kwesibindi/izinso noma kubangela i-gout njalo.Kumagundane, ukuguqulwa kofuzo olufaka ikhodi ye-uricase kubangela ukwanda okungazelelwe kwe-uric acid.Amagundane, ashoda kulesi sakhi sofuzo, akhombisa i-hyperuricemia, hyperuricosuria, kanye ne-uric acid crystalline obstructive nephropathy.
Isakhiwo Samakhemikhali
Isimiso Sokusabela
I-Uric acid+O2+2H2O→ I-Allantoin + CO2+ H2O2
Ukucaciswa
| Izinto Zokuhlola | Imininingwane |
| Incazelo | Impushana emhlophe e-amorphous, i-lyophilized |
| Umsebenzi | ≥20U/mg |
| Ubumsulwa(SDS-PAGE) | ≥90% |
| Ukunyibilika (10mg powder/ml) | Kucace |
| Iqukethe ama-enzyme | |
| I-NADH/NADPH oxidase | ≤0.01% |
| IsiCatalase | ≤0.03% |
Ezokuthutha nokugcina
Ezokuthutha:Kuthunyelwa ngaphansi kuka-20°C
Isitoreji :Gcina ku -20°C(Isikhathi eside), 2-8°C(Isikhathi esifushane)
Ukuhlola kabusha okunconyiweImpilo:2 iminyaka
